Avian Pancreatic Polypeptide (APP)

Avian Pancreatic Polypeptide (APP), a 36-residue polypeptide with some hormonal properties. The aPP molecules form a symmetrical dimer in the crystal stabilized principally by interlocking of nonpolar groups from the α-helices. The aPP dimers are crosslinked by coordination of Zn2+; three aPP molecules contribute ligands to each zinc. The coordination geometry is a distorted trigonal bipyramid. The properties of the aPP molecule in solution are consistent with expectations based on the crystal structure. The aPP molecule has several general features in common with the pancreatic hormones insulin and glucagon. All three hormones have complex mechanisms for self-association. Like insulin, aPP seems to have a stable monomeric structure but its biological activity seems to depend on the more flexible COOH-terminal region analogous to the flexible NH2-terminal region of glucagon.