Transmembrane Protein 27 (TMEM27)

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NX17; Collectrin

Transmembrane Protein 27 (TMEM27)

TMEM27 encodes a transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. TMEM27 has an N-terminal signal sequence, followed by a noncatalytic extracellular domain, a transmembrane segment, and a cytosolic domain. The extracellular domain contains an O-glycosylation site and 2 N-glycosylation sites. Human TMEM27 shares 47.8% identity with the C-terminal end of ACE2, but it lacks an ACE2-like catalytic domain. Northern blot analysis of rat, mouse, and human tissues detected a transcript of about 1.8 kb exclusively in kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK477Hu01 Recombinant Transmembrane Protein 27 (TMEM27) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK477Hu01 Polyclonal Antibody to Transmembrane Protein 27 (TMEM27) WB
LAK477Hu71 Biotin-Linked Polyclonal Antibody to Transmembrane Protein 27 (TMEM27) WB
MAK477Hu21 Monoclonal Antibody to Transmembrane Protein 27 (TMEM27) WB
MAK477Hu22 Monoclonal Antibody to Transmembrane Protein 27 (TMEM27) IHC
MAK477Hu23 Monoclonal Antibody to Transmembrane Protein 27 (TMEM27) WB; IHC; ICC; IP.
MAK477Hu24 Monoclonal Antibody to Transmembrane Protein 27 (TMEM27) WB; IHC; ICC; IP.
MAK477Hu25 Monoclonal Antibody to Transmembrane Protein 27 (TMEM27) WB
Assay Kits SEK477Hu ELISA Kit for Transmembrane Protein 27 (TMEM27) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK477Mu01 Recombinant Transmembrane Protein 27 (TMEM27) Positive Control; Immunogen; SDS-PAGE; WB.
RPK477Mu02 Recombinant Transmembrane Protein 27 (TMEM27) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK477Mu01 Polyclonal Antibody to Transmembrane Protein 27 (TMEM27) WB; IHC; ICC; IP.
PAK477Mu02 Polyclonal Antibody to Transmembrane Protein 27 (TMEM27) WB; IHC
MAK477Mu21 Monoclonal Antibody to Transmembrane Protein 27 (TMEM27) WB; IHC
Assay Kits SEK477Mu ELISA Kit for Transmembrane Protein 27 (TMEM27) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK477Ra01 Recombinant Transmembrane Protein 27 (TMEM27) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK477Ra01 Polyclonal Antibody to Transmembrane Protein 27 (TMEM27) IHC
MAK477Ra21 Monoclonal Antibody to Transmembrane Protein 27 (TMEM27) WB; IHC; ICC; IP.
Assay Kits SEK477Ra ELISA Kit for Transmembrane Protein 27 (TMEM27) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK477Ca01 Recombinant Transmembrane Protein 27 (TMEM27) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAK477Ca21 Monoclonal Antibody to Transmembrane Protein 27 (TMEM27) WB; IHC; ICC; IP.
PAK477Ca01 Polyclonal Antibody to Transmembrane Protein 27 (TMEM27) WB; IHC; ICC; IP.
Assay Kits SEK477Ca ELISA Kit for Transmembrane Protein 27 (TMEM27) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys."J. Biol. Chem. 276:17132-17139(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation." Cell Metab. 2:373-384(2005) [PubMed] [Europe PMC] [Abstract]
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