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F-Box And WD Repeat Domain Containing Protein 7 (FBXW7)

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AGO; CDC4; FBW7; FBX30; FBXW6; SEL-10; SEL10; Archipelago Homolog; F-box and WD-40 domain-containing protein 7

F-Box And WD Repeat Domain Containing Protein 7 (FBXW7)
CCC J890
HGNC 16712
MGI 1354695
PubMed 23518349
UniProt Q969H0
Wiki FBXW7
FBXW7 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ890Hu01 Recombinant F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ890Hu01 Polyclonal Antibody to F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ890Mu01 Recombinant F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ890Mu01 Polyclonal Antibody to F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) CLIA Kit Customized Service Offer
n/a ELISA Kit for F-Box And WD Repeat Domain Containing Protein 7 (FBXW7) ELISA Kit Customized Service Offer
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  9. "Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7."EMBO J. 23:2116-2125(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling."Science 303:1374-1378(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4."J. Biol. Chem. 280:7654-7658(2005) [PubMed] [Europe PMC] [Abstract]
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  13. "The ubiquitin-specific protease USP28 is required for MYC stability."Nat. Cell Biol. 9:765-774(2007) [PubMed] [Europe PMC] [Abstract]
  14. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase."J. Cell Sci. 124:100-112(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase."Mol. Cell 46:771-783(2012) [PubMed] [Europe PMC] [Abstract]
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  18. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases."Mol. Cell 26:131-143(2007) [PubMed] [Europe PMC] [Abstract]