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GLI Family Zinc Finger Protein 3 (GLI3)

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GCPS, PHS; PAP-A; PAPA; PAPA1; PAPB; ACLS; PPDIV; Greig Cephalopolysyndactyly Syndrome; Glioma-Associated Oncogene Family Zinc Finger 3; GLI3 form of 190 kDa

GLI Family Zinc Finger Protein 3 (GLI3)
CCC J716
HGNC 4319
MGI 95729
PubMed 2118997
UniProt P10071
Wiki GLI3
GLI3 encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.Is expressed in a wide variety of normal adult tissues, including lung, colon, spleen, placenta, testis, and myometrium. The extent of this transcript is supported by transcript alignments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ716Hu01 Recombinant GLI Family Zinc Finger Protein 3 (GLI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ716Hu01 Polyclonal Antibody to GLI Family Zinc Finger Protein 3 (GLI3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for GLI Family Zinc Finger Protein 3 (GLI3) CLIA Kit Customized Service Offer
n/a ELISA Kit for GLI Family Zinc Finger Protein 3 (GLI3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ716Mu01 Recombinant GLI Family Zinc Finger Protein 3 (GLI3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ716Mu01 Polyclonal Antibody to GLI Family Zinc Finger Protein 3 (GLI3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for GLI Family Zinc Finger Protein 3 (GLI3) CLIA Kit Customized Service Offer
n/a ELISA Kit for GLI Family Zinc Finger Protein 3 (GLI3) ELISA Kit Customized Service Offer
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  2. "Point mutations throughout the GLI3 gene cause Greig cephalopolysyndactylysyndrome." Hum. Mol. Genet. 8:1769-1777(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
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  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb."Cell 100:423-434(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Physical and functional interactions between Zic and Gli proteins."J. Biol. Chem. 276:6889-6892(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP."Mol. Cell. Biol. 26:4316-4326(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing."Proc. Natl. Acad. Sci. U.S.A. 103:33-38(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling."Cell 133:537-548(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of the interactions of human ZIC3 mutants with GLI3."Hum. Mutat. 29:99-105(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development."Curr. Biol. 19:1320-1326(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3."Dev. Biol. 328:40-53(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway."Exp. Cell Res. 316:627-637(2010) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Point mutations in human GLI3 cause Greig syndrome."Hum. Mol. Genet. 6:1979-1984(1997) [PubMed] [Europe PMC] [Abstract]
  19. "The phenotypic spectrum of GLI3 morphopathies includes autosomal dominant preaxial polydactyly type-IV and postaxial polydactyly type-A/B; no phenotype prediction from the position of GLI3 mutations."Am. J. Hum. Genet. 65:645-655(1999) [PubMed] [Europe PMC] [Abstract]
  20. "De novo GLI3 mutation in acrocallosal syndrome: broadening the phenotypic spectrum of GLI3 defects and overlap with murine models."J. Med. Genet. 39:804-806(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Variable phenotype in Greig cephalopolysyndactyly syndrome: clinical and radiological findings in 4 independent families and 3 sporadic cases with identified GLI3 mutations."Am. J. Med. Genet. A 120:49-58(2003) [PubMed] [Europe PMC] [Abstract]
  22. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]