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H2A Histone Family, Member Z (H2AFZ)

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H2A.z; H2A/z; H2AZ; H2A/z

H2A Histone Family, Member Z (H2AFZ)
CCC J705
HGNC 4741
MGI 1888388
PubMed 16098230
RGD 621464
UniProt P0C0S5
Wiki H2AFZ
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
H2AFZ encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ705Mi01 Recombinant H2A Histone Family, Member Z (H2AFZ) Positive Control; Immunogen; SDS-PAGE; WB.
RPJ705Hu01 Recombinant H2A Histone Family, Member Z (H2AFZ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ705Mi01 Polyclonal Antibody to H2A Histone Family, Member Z (H2AFZ) WB; IHC; ICC; IP.
PAJ705Hu01 Polyclonal Antibody to H2A Histone Family, Member Z (H2AFZ) WB; IHC; ICC; IP.
Assay Kits SEJ705Mi ELISA Kit for H2A Histone Family, Member Z (H2AFZ) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ705Mi01 Recombinant H2A Histone Family, Member Z (H2AFZ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ705Mi01 Polyclonal Antibody to H2A Histone Family, Member Z (H2AFZ) WB; IHC; ICC; IP.
Assay Kits SEJ705Mi ELISA Kit for H2A Histone Family, Member Z (H2AFZ) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ705Mi01 Recombinant H2A Histone Family, Member Z (H2AFZ) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAJ705Mi01 Polyclonal Antibody to H2A Histone Family, Member Z (H2AFZ) WB; IHC; ICC; IP.
Assay Kits SEJ705Mi ELISA Kit for H2A Histone Family, Member Z (H2AFZ) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species."Nucleic Acids Res. 16:1113-1124(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The human histone H2A.Z gene. Sequence and regulation."J. Biol. Chem. 265:15211-15218(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z."J. Biol. Chem. 280:25298-25303(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Precise characterization of human histones in the H2A gene family by top down mass spectrometry."J. Proteome Res. 5:248-253(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative proteomic analysis of post-translational modifications of human histones."Mol. Cell. Proteomics 5:1314-1325(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry."Mol. Cell. Proteomics 5:541-552(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of a nucleosome core particle containing the variant histone H2A.Z."Nat. Struct. Biol. 7:1121-1124(2000) [PubMed] [Europe PMC] [Abstract]
  13. "ANP32E is a histone chaperone that removes H2A.Z from chromatin."Nature 505:648-653(2014) [PubMed] [Europe PMC] [Abstract]