≡

Biliverdin Reductase A (BLVRA)

[Edit]

BLVR; BVR; Biliverdin-IX alpha-reductase

Biliverdin Reductase A (BLVRA)
CCC J551
HGNC 1062
MGI 88170
PubMed 23536765
RGD 620721
UniProt P53004
Biliverdin reductases, such as BLVRA (EC 1.3.1.24), catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH.
The deduced 296-amino acid protein has a calculated molecular mass of 33.2 kD. Removal of 2 N-terminal amino acids results in a 294-amino acid mature protein with an N-terminal threonine. The N-terminal region contains the NADH/NADPH-binding consensus sequence. BLVRA shares 82.8% amino acid identity with rat Blvra, but it does not share significant homology with BLVRB. Northern blot analysis detected BLVRA at 1.35 kb in all 8 tissues examined. Expression was highest in brain, pancreas, and lung, and lowest in liver and placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ551Hu01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ551Hu21 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAJ551Hu01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC
Assay Kits SEJ551Hu ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ551Mu01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
APJ551Mu01 Active Biliverdin Reductase A (BLVRA) Cell culture; Activity Assays.
Antibodies PAJ551Mu01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB
Assay Kits SEJ551Mu ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPJ551Ra01 Recombinant Biliverdin Reductase A (BLVRA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAJ551Ra21 Monoclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC; ICC; IP.
PAJ551Ra01 Polyclonal Antibody to Biliverdin Reductase A (BLVRA) WB; IHC
Assay Kits SEJ551Ra ELISA Kit for Biliverdin Reductase A (BLVRA) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and characterization of the cDNA encoding human biliverdin-IX alpha reductase."Biochim. Biophys. Acta 1309:89-99(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes."Eur. J. Biochem. 235:372-381(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Purification and characterization of human biliverdin reductase."Arch. Biochem. Biophys. 300:320-326(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from human liver. Purification and characterization."J. Biol. Chem. 269:24343-24348(1994) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice)."Liver Int. 29:1116-1124(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of human biliverdin reductase A."Submitted (FEB-2009) to the PDB data bank