Cystatin B (CSTB)
[Edit]Cys-B; CST6; EPM1; PME; STFB; CPI-B; Stefin B; Liver thiol proteinase inhibitor
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The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens.
CysB encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ322Hu01 | Recombinant Cystatin B (CSTB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ322Hu01 | Polyclonal Antibody to Cystatin B (CSTB) | WB;IHC;ICC/IF;FCM |
| MAJ322Hu21 | Monoclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC; IP. | |
| Assay Kits | SEJ322Hu | ELISA Kit for Cystatin B (CSTB) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ322Mu01 | Recombinant Cystatin B (CSTB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ322Mu01 | Polyclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC; IP. |
| LAJ322Mu71 | Biotin-Linked Polyclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Cystatin B (CSTB) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cystatin B (CSTB) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ322Ra01 | Recombinant Cystatin B (CSTB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ322Ra01 | Polyclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC; IP. |
| LAJ322Ra71 | Biotin-Linked Polyclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC. | |
| MAJ322Ra21 | Monoclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC; IP. | |
| MAJ322Ra24 | Monoclonal Antibody to Cystatin B (CSTB) | WB | |
| LAJ322Ra74 | Biotin-Linked Monoclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC. | |
| MAJ322Ra26 | Monoclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC; IP. | |
| MAJ322Ra22 | Monoclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC; IP. | |
| Assay Kits | SEJ322Ra | ELISA Kit for Cystatin B (CSTB) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPJ322Bo01 | Recombinant Cystatin B (CSTB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAJ322Bo01 | Polyclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC; IP. |
| LAJ322Bo71 | Biotin-Linked Polyclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC. | |
| LAJ322Bo81 | FITC-Linked Polyclonal Antibody to Cystatin B (CSTB) | WB; IHC; ICC; IF. | |
| Assay Kits | n/a | CLIA Kit for Cystatin B (CSTB) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cystatin B (CSTB) | ELISA Kit Customized Service Offer |
- "Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver."Biochem. Biophys. Res. Commun. 131:1187-1192(1985) [PubMed] [Europe PMC] [Abstract]
- "Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1)."Science 271:1731-1734(1996) [PubMed] [Europe PMC] [Abstract]
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- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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- "Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1)."Am. J. Hum. Genet. 60:342-351(1997) [PubMed] [Europe PMC] [Abstract]