MKN45 is a widely - studied human gastric cancer cell line. It was established by Hojo H from the liver metastasis of a 62-yea -old Japanese female patient with poorly differentiated gastric adenocarcinoma.
These cells display a semi-adherent and semi-suspension growth pattern. They can appear as spindle - shaped or oval - shaped cells in monolayers, as well as single round cells or cell clumps in suspension. MKN45 cells have a hyper - triploid karyotype with 8% polyploidy. Biochemically, they are notable for producing a high level of carcinoembryonic antigen (CEA).
In research, MKN45 cells are invaluable. They serve as an excellent model for studying the biological characteristics of gastric cancer, including cancer cell growth, metastasis mechanisms, and drug resistance. For example, they can be used to screen potential anti - gastric - cancer drugs and explore the underlying immunological pathways related to the disease.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Cells | CSI900Hu11 | Human MKN45 Gastric Cancer Cells (MKN45) | MKN45 is often used in EMT (epithelial-mesenchymal transition) studies and Commonly employed for testing chemotherapeutic agents and targeted therapies. |
| Extracts | n/a | Extract of MKN45 Gastric Cancer Cells (MKN45) | Total Protein/DNA/RNA Extract Customized Service Offer |
| Mediums | n/a | Medium for MKN45 Gastric Cancer Cells (MKN45) (If Necessary) | Cell Culture Medium Customized Service Offer |