Occlusive Angitis (OA)

Thromboangiitis obliterans, also known as Buerger disease, is a recurring progressive inflammation and thrombosis (clotting) of small and medium arteries and veins of the hands and feet. It is strongly associated with use of tobacco products, primarily from smoking, but is also associated with smokeless tobacco.

The transfer of VEGF gene can stimulate the formation of focal neovessles , estab- lish colleteral circulation , augment blood perfusion , and ameliorate distal limb necrosis. Conclusion These findings reveal that the " molecular bypass" using VEGF gene may represent a potential therapeu- tic modality for treating tissue ischemia.