LX-2 Hepatic Stellate Cells (LX-2)

LX-2 cell line is a human hepatic stellate cell line that has been widely used in research focused on liver fibrosis, hepatic stellate cell biology, and liver-related diseases. LX-2 cells were derived from primary human hepatic stellate cells and immortalized using simian virus 40 large T antigen, making them a valuable in vitro model for studying hepatic fibrogenesis and the activation of hepatic stellate cells in response to liver injury.

Hepatic stellate cells play a crucial role in liver fibrosis, a pathological process characterized by excessive accumulation of extracellular matrix proteins in the liver in response to chronic injury or inflammation. The activation of hepatic stellate cells into myofibroblast-like cells is a key step in the progression of liver fibrosis, leading to increased production of collagen and other fibrotic proteins.

Studies utilizing the LX-2 cell line have contributed to our understanding of the complex interactions between different cell types, signaling molecules, and pathways involved in liver fibrosis. By manipulating LX-2 cells in vitro, researchers can explore potential therapeutic targets for inhibiting hepatic stellate cell activation and reducing fibrotic scarring in the liver.