KGN Ovarian Granulosa Cells (KGN)

KGN cell line is a human granulosa-like tumor cell line that has gained significance in reproductive biology and ovarian cancer research. Derived from a granulosa cell tumor of the ovary, the KGN cell line exhibits characteristics akin to primary granulosa cells, making it a valuable tool for studying ovarian physiology, granulosa cell function, and reproductive disorders.

KGN cells maintain their granulosa cell-like phenotype in culture, expressing key markers associated with granulosa cell differentiation and steroidogenesis. Researchers commonly use the KGN cell line to investigate the molecular mechanisms underlying ovarian follicle development, steroid hormone production, and the pathogenesis of granulosa cell tumors.

Studies utilizing the KGN cell line have provided insights into the regulation of ovarian function, follicle growth, and hormone signaling pathways. By manipulating KGN cells in vitro, researchers have identified novel genes, signaling cascades, and hormonal factors that influence granulosa cell behavior and ovarian function.