HT29 Colon Carcinoma Cells (HT29)

HT29 cells are a well-established human cell line derived from a colorectal adenocarcinoma. These cells have been widely used in biomedical and cancer research due to their ability to mimic the characteristics of colorectal cancer cells and their responsiveness to various stimuli commonly found in the tumor microenvironment.

Originally isolated from a primary tumor in a 44-year-old patient, HT29 cells exhibit epithelial morphology and maintain the ability to differentiate into polarized structures in culture. The HT29 cell line is characterized by its ability to grow rapidly, form well-defined monolayers, and express markers commonly found in colorectal cancer cells, such as carcinoembryonic antigen (CEA) and epithelial cell adhesion molecule (EpCAM).

Researchers utilize HT29 cells to study various aspects of colorectal cancer biology, including tumor cell proliferation, invasion, metastasis, and response to chemotherapy. These cells are valuable tools for investigating the molecular mechanisms underlying colorectal cancer development and progression, as well as for exploring potential therapeutic interventions targeting specific pathways involved in tumorigenesis.