HCT8 Colon Carcinoma Cells (HCT8)

HCT8 cell line is another well-known human cell line derived from a colorectal adenocarcinoma, similar to the HT29 cell line. HCT8 cells were established from the colon of a 64-year-old male patient with colorectal adenocarcinoma and have been extensively used in cancer research due to their relevance in studying colorectal cancer biology and treatment.

HCT8 cells exhibit epithelial morphology and characteristics typical of colorectal cancer cells. They are capable of forming monolayers in culture and expressing markers associated with colorectal cancer, such as CEA and EpCAM. HCT8 cells are also responsive to various stimuli encountered in the tumor microenvironment, making them valuable tools for investigating cancer cell behavior and response to treatments.

Researchers utilize HCT8 cells to study key aspects of colorectal cancer, including cell proliferation, invasion, metastasis, and drug sensitivity. The cell line's ability to recapitulate features of colorectal adenocarcinoma makes it a valuable model for exploring the molecular mechanisms underlying tumor development and progression.