Cal-27 Tongue Squamous Carcinoma Cells (Cal-27)

Cal-27 cell line is a human oral squamous cell carcinoma cell line that was derived from a tumor specimen obtained from a patient with oral cavity cancer. The Cal-27 cell line was established in the 1970s by Dr. J. Sanford and colleagues at the University of California, San Francisco.

Cal-27 cells exhibit characteristics typical of squamous epithelial cells and have been extensively used in cancer research, particularly in studies focusing on oral cavity cancers, as well as in investigating various aspects of cellular biology, including cell signaling pathways, gene expression, and drug sensitivity testing.

Cal-27 cell line has been instrumental in advancing our understanding of the molecular mechanisms underlying the development and progression of oral cavity cancers, providing researchers with a valuable tool for studying tumor biology, drug resistance mechanisms, and potential therapeutic interventions.

Furthermore, Cal-27 cells have been employed to investigate the effects of various chemical and biological agents on cancer cell growth and survival, as well as to screen potential anti-cancer drugs and therapies targeting squamous cell carcinomas and related malignancies.