NB4 cell line: The NB4 cell line is a human acute promyelocytic leukemia cell line that was established from the bone marrow of a patient with acute promyelocytic leukemia. NB4 cells are frequently used in leukemia research to study promyelocytic leukemia biology, myeloid differentiation, and response to therapeutic agents. These cells have been crucial in elucidating the molecular mechanisms underlying acute promyelocytic leukemia pathogenesis, such as chromosomal translocations involving the retinoic acid receptor gene, and in developing novel treatment strategies for this subtype of leukemia.
