Luciferase B16 Melanoma Cells (B16-Luc)

B16-Luc cells are a specific cell line derived from murine melanoma cells that have been genetically modified to express a luciferase reporter gene. Luciferase is an enzyme that catalyzes a reaction with its substrate, luciferin, resulting in the emission of visible light. By introducing the luciferase gene into the B16 melanoma cells, researchers can track the growth, spread, and response to treatments of these cells in animal models through non-invasive bioluminescence imaging.

The use of B16-Luc cells in research has provided valuable insights into melanoma biology, tumor progression, metastasis, and response to therapeutic interventions. By monitoring the bioluminescent signal emitted by the cells, researchers can visualize tumor growth and metastatic spread in real-time, enabling longitudinal studies and precise assessment of treatment efficacy.