Luciferas A549-GFP Lung Carcinomar Cells (A549-GFP-Luc)

A549-LUC cell line is a widely used human lung cancer cell line that has been engineered to express the luciferase gene, enabling researchers to monitor tumor growth and metastasis in live animal models using bioluminescence imaging. The A549 cell line was originally derived from a lung adenocarcinoma in a male patient and has since become a valuable tool for studying lung cancer biology and testing new therapeutic approaches.

By introducing the luciferase reporter gene into the A549 cell line, scientists can track the growth and spread of lung tumors in real-time through bioluminescence imaging, a non-invasive technique that allows for the visualization and quantification of cancer cells in live animals. This technology has revolutionized preclinical research by providing insights into tumor progression, response to treatment, and metastatic dissemination.

The A549-LUC cell line is particularly useful for studying lung cancer metastasis, as it recapitulates key features of aggressive lung tumors in patients. Researchers can investigate the mechanisms underlying tumor invasion, metastatic spread to distant sites, and interactions with the immune system using this model system, ultimately leading to the development of novel therapies for lung cancer.