THP-1 Monocytic in Leukemia Cells (THP-1)

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THP1

THP-1 Monocytic in Leukemia Cells (THP-1)

THP-1 cell line is a human monocytic leukemia cell line that was established from the peripheral blood of a 1-year-old infant with acute monocytic leukemia. THP-1 cells have been widely used in research related to immunology, inflammation, and cancer due to their ability to differentiate into macrophage-like cells in response to various stimuli.

THP-1 cells exhibit characteristics of monocytic cells and can be induced to differentiate into macrophage-like cells by treatment with phorbol esters such as phorbol 12-myristate 13-acetate (PMA) or other differentiation agents. This differentiation process changes their morphology, gene expression profile, and functional properties, making them a valuable model for studying monocyte/macrophage biology and functions.

THP-1 cells have been used to investigate various aspects of innate immunity, inflammatory responses, host-pathogen interactions, and the role of macrophages in diseases such as cancer, infectious diseases, and autoimmune disorders. Furthermore, THP-1 cells have been employed in drug screening assays, studying signal transduction pathways, and evaluating the immunomodulatory effects of different compounds.


Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Cells CSI400Hu11 Human THP-1 Monocytic in Leukemia Cells (THP-1) THP-1 cell line is used in vitro model for studying various aspects of monocyte/macrophage biology, inflammation, and immune responses.
Extracts n/a Extract of THP-1 Monocytic in Leukemia Cells (THP-1) Total Protein/DNA/RNA Extract Customized Service Offer
Mediums MSI400Hu11 Medium for Human THP-1 Monocytic in Leukemia Cells (THP-1) Complete Medium for the culture of THP-1 cell line