C28/I2 Chondrocytes (C28/I2)

C28/I2 cell line is a human chondrocyte cell line that was derived from articular cartilage obtained from the knee joint of an adult male cadaver. These cells were immortalized using the SV40 large T antigen and have since become a valuable tool in research focusing on cartilage biology, osteoarthritis, and musculoskeletal disorders.

C28/I2 cells exhibit several characteristics that make them well-suited for studying cartilage biology and joint diseases. They maintain a chondrocyte-like phenotype in culture, express key markers of mature chondrocytes, and have the ability to produce extracellular matrix components typical of articular cartilage, such as collagen types II, IX, and XI.

 C28/I2 cell line represents a valuable resource for researchers interested in exploring the complexities of cartilage biology and the pathophysiology of osteoarthritis. Its characterization as an immortalized human chondrocyte cell line has made it an indispensable tool for studying cartilage-related diseases and advancing our understanding of joint health and disease mechanisms.