PANC-1 Pancreatic Cancer Cells (PANC-1)

The PANC-1 cell line is a human pancreatic epithelioid carcinoma cell line that was established from the pancreatic carcinoma tissue of a 56-year-old Caucasian male in 1975. PANC-1 cells are widely used in cancer research to study pancreatic cancer biology, tumor progression, and therapeutic interventions. These cells exhibit characteristics of pancreatic adenocarcinoma, such as high proliferation rate, epithelial morphology, and tumorigenic potential in xenograft models.

The PANC-1 cell line has been instrumental in elucidating molecular mechanisms underlying pancreatic cancer pathogenesis, including genetic mutations, signaling pathways, and interactions with the tumor microenvironment. Researchers have used PANC-1 cells to study key features of pancreatic cancer, such as abnormal cell growth, metastasis, invasion, and resistance to chemotherapy. Additionally, PANC-1 cells have been valuable for evaluating novel therapeutic approaches targeting pancreatic cancer, such as targeted therapies, immunotherapies, and combination treatments.