U-87 MG

The U-87 MG cell line is a well-known and extensively studied human glioblastoma cell line that was derived from a malignant brain tumor in 1968. Named after the patient from whom the tumor was taken, U-87 MG cells have become a valuable model system for research in neuro-oncology, cancer biology, drug development, and molecular studies related to brain tumors.

Originating from a grade III astrocytoma, the U-87 MG cell line retains key characteristics of glioblastoma multiforme (GBM), the most common and aggressive form of primary brain cancer. These cells exhibit features of malignant glioma cells, including high proliferation rates, invasive growth, resistance to apoptosis, and altered signaling pathways associated with cancer progression.

U-87 MG cell line plays a crucial role in advancing our understanding of glioblastoma biology, cancer therapy, and drug discovery efforts. Its relevance as a model system for GBM research has led to significant contributions to the field of neuro-oncology, with implications for the development of innovative treatments and personalized medicine approaches for patients with brain tumors. Continued utilization of the U-87 MG cell line in research endeavors is essential for furthering our knowledge of glioblastoma and improving clinical outcomes for individuals affected by this devastating disease.