Renal Parenchymal Cells (RPC)

The parenchyma is the functional parts of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, namely, the connective tissues. In the brain, the parenchyma refers to the functional tissue in the brain that is made up of the two types of brain cell, neurons and glial cells. Damage or trauma to the brain parenchyma often results in a loss of cognitive ability or even death. Lung parenchyma is the substance of the lung outside of the circulation system that is involved with gas exchange and includes the alveoli and respiratory bronchioles.

GM-CSF has previously been demonstrated to be important in crescentic glomerulonephritis. Renal parenchymal cells can produce and infiltrating inflammatory cells produce GM-CSF.