Ovarian Microvascular Endothelial Cells (OMEC)

Microvascular endothelial cells play a central role in inflammation, tumor metastasis, wound healing and tissue engineering. They lead to many biological processes, such as hemostasis, coagulation, and lymphocyte trafficking. Microvascular endothelial cells migrate to the damaged site to form a new blood vessel. Then platelet and inflammatory cells and activated endothelial cells will release of growth factors, such as TGFβ, PDGF, epidermal growth factor, FGF and profibrotic cytokines such as IL-1 and TNFα. These factors can promot mononuclear macrophage and fibroblast proliferation and migration. Ovarian microvascular endothelial cells (OMEC) are an ideal in vitro model for the study of the angiogenesis and physiology of the female reproductive system. OMEC are prepared from the specific microvasculature of the ovarian follicle.