Gingival Fibroblasts (GF)

Fibroblasts are mesenchymal cells which perform many vital functions during development and in adulthood. They are responsible for much of the synthesis of extracellular matrix in connective tissue and play major roles in wound healing. Many diseases are associated with fibroblasts, either because fibroblasts are implicated in their etiology or because of the fibrosis that accompanies damage to other cell types. Fibroblasts are one of the most accessible mammalian cell types and one of the easiest types of cells to grow in culture.

Gingival fibroblasts (GF) are the main component of the gingival tissue. They plays a key role in the protection and repair of periodontal tissues. Studies suggested that aging in human gingival fibroblasts (HGFs) may be one of the factors that take part in the stimulation of C.rectus LPS-stimulated PGE2 production in old cells. The human gingival fibroblast cells also can be used to evaluate the antimicrobial photodynamic therapy with indocyanine green and curcumin.