Cervical Microvascular Endothelial Cells (CMEC)

Cervix is the female reproductive system in vital organs and tissues, is positioned on the lower part of the uterus, approximate cone function is promoting reproduction and protection of female genital tract and fetal free of potentially pathogenic bacteria effect.

Vascular endothelial cells lining the blood vessels actively participate in many vital biological processes. Cervical Microvascular Endothelial Cells (CMEC) limit the passage of cellular and soluble substances between the blood vessels and the surrounding tissues. CMEC also play critical roles in angiogenesis, vasculogenesis, and the inflammatory response. Cervical Microvascular Endothelial Cells angiogenesis has been shown to contribute to the progression of cervical cancer. Recent studies suggest that CMEC may even initiate signaling events which directly promote tumor growth. Cultured human CMEC  are a useful model to elucidate the mechanisms of normal and pathological angiogenesis and develop therapeutic treatments for cervical cancer.