Intestinal Smooth Muscle Cells (ISMC)

Smooth muscle cells are connected to each other, to form a tubular structure or a hollow organ; they can produce continuous contraction or tonic contraction, make organs against the load while maintaining the original shape.

Intestinal smooth muscle cells strip devoid of enteric nerve cells can contract in response to stretch, researches showed that the presence of a stretch-activated calcium channel in gastrointestinal smooth muscle cells may allow the smooth muscle cells to act directly as mechanotransducers and to participate in the regulation of smooth muscle tone and intestinal motility.IL-1 beta interacts with its receptor on smooth muscle cells to induce transcription of the IL-6 gene and to cause the secretion of IL-6. These results indicate that intestinal smooth muscle cells are not only targets for but also a source of cytokine. Intestinal inflammation can lead to the increase of the level of specific actin in smooth muscle cells, thereby promoting the thickening of the smooth muscle layer. Intestinal smooth muscle cells can be used to study the intestinal smooth muscle contraction and proliferation of tissue reaction.