Renal Artery Smooth Muscle Cells (RASMC)

The potential of primary cultures of rabbit renal artery vascular smooth muscle cells (RVSMCs) is assessed as a means to investigate the signalling pathways linked to 5-hydroxytryptamine (5-HT) 5-HT(1B)/5-HT(1D) receptors in native arteries. Results indicate that primary cultures of  renal artery smooth muscle cellscould provide a model system to study further the signalling pathways linked to these receptors.

Renal artery smooth muscle cells express the calcium channel and ICAM-1 and VCAM-1and these cytokines in the inflammatory reaction in the vessel wall, and is associated with the progression of vascular disease and stability. Human renal artery smooth muscle cells are related with renal artery stenosis, renal artery aneurysm, renal artery embolism and renal atherosclerosis and other diseases. Cultured RVSMCs plays an important role in the identification of new therapeutic targets for arterial disease.