Choroid Plexus Fibroblasts (CPF)

Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies as they are one of the easiest types of cells to grow in culture. Their durability also makes them amenable to a wide variety of manipulations ranging from studies employing gene transfection to microinjection. Fibroblasts are the most common cells of connective tissue in animals. Fibroblasts in various parts of the body are intrinsically different. Many diseases are associated with fibroblasts, either because fibroblasts are implicated in their etiology or because of the fibrosis that accompanies damage to other cell types. A serotonin (5-HT)-mediated phosphoinositide hydrolysis response was characterized in fibroblasts cultured from rabbit choroid plexus.In a previous study, choroid plexus fibroblasts (CPF) have been used to study the roles of the macrophage as a virus target cell and virus inducer in the virus-macrophage-fibroblast interaction.