Umbilical Vein Endothelial Cells (UVEC)

Umbilical vein endothelial cells (UVECs) are cells derived from the endothelium of veins from the umbilical cord. Porphyromonas gingivalis induces nitric oxide (NO) synthesis in human umbilical vein endothelial cells. Peroxisome proliferator-activated receptor (PPARγ) has an anti-inflammation function, and its involvement in this NO induction process requires elucidation.Researchers focused on PPARγ expression in UVECs exposed to P. gingivalis, and investigated its effects on NO synthesis.

Umbilical vein endothelial cells have played a major role as a model system for the study of the regulation of endothelial cell function and the role of the endothelium in the response of the blood vessel wall to stretch, shear forces, and the development of atherosclerotic plaques and angiogenesis.