Prostate Microvascular Endothelial Cells (PrMEC)

Microvascular endothelial cells play a central role in inflammation, tumor metastasis, wound healing and tissue engineering. They lead to many biological processes, such as hemostasis, coagulation, and lymphocyte trafficking. Microvascular endothelial cells migrate to the damaged site to form a new blood vessel. Then platelet and inflammatory cells and activated endothelial cells will release of growth factors, such as TGFβ, PDGF, epidermal growth factor, FGF and profibrotic cytokines such as IL-1 and TNFα. These factors can promot mononuclear macrophage and fibroblast proliferation and migration. In prostate cancer, microvascular endothelial cells play an important role in the interaction of prostate tumor metastasis. Some studies have indicated that the prostate microvascular endothelial cells (PrMEC) can actively participate in the growth of the prostate, through the secretion of regulatory factors such as IL6.