T-Box Protein 3 (TBX3)

[Edit]

TBX3-ISO; UMS; XHL; Ulnar Mammary Syndrome

T-Box Protein 3 (TBX3)
TBX3 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.The complete open reading frame of the TBX3 gene encodes a predicted 723-amino acid protein, of which 255 amino acids are encoded by newly identified exons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH858Hu01 Recombinant T-Box Protein 3 (TBX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH858Hu01 Polyclonal Antibody to T-Box Protein 3 (TBX3) WB
LAH858Hu71 Biotin-Linked Polyclonal Antibody to T-Box Protein 3 (TBX3) WB; IHC; ICC.
MAH858Hu21 Monoclonal Antibody to T-Box Protein 3 (TBX3) WB; IHC; ICC; IP.
Assay Kits SEH858Hu ELISA Kit for T-Box Protein 3 (TBX3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH858Mu01 Recombinant T-Box Protein 3 (TBX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH858Mu01 Polyclonal Antibody to T-Box Protein 3 (TBX3) WB; IHC; ICC; IP.
LAH858Mu71 Biotin-Linked Polyclonal Antibody to T-Box Protein 3 (TBX3) WB; IHC; ICC.
PAH858Mu02 Polyclonal Antibody to T-Box Protein 3 (TBX3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for T-Box Protein 3 (TBX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Box Protein 3 (TBX3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH858Ra01 Recombinant T-Box Protein 3 (TBX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH858Ra01 Polyclonal Antibody to T-Box Protein 3 (TBX3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for T-Box Protein 3 (TBX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Box Protein 3 (TBX3) ELISA Kit Customized Service Offer
  1. "Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome."Proc. Natl. Acad. Sci. U.S.A. 96:10212-10217(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome."Nat. Genet. 16:311-315(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The spectrum of mutations in TBX3: genotype/phenotype relationship in ulnar-mammary syndrome."Am. J. Hum. Genet. 64:1550-1562(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence."EMBO J. 31:95-109(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome."Structure 10:343-356(2002) [PubMed] [Europe PMC] [Abstract]