Klotho Beta (KLb)

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Klotho beta-like protein

Klotho Beta (KLb)
KLb encodes a 1,043-amino acid protein that shares 41.2% identity with mouse Kl. Like Kl, Klb contains an N-terminal signal sequence, followed by 2 tandemly repeated glycosidase-like domains, a C-terminal transmembrane domain, and a short cytoplasmic tail. Both Kl and Klb lack 2 key glutamates in the predicted active centers of the glycosidase-like domains.
Northern blot analysis of adult mouse tissues showed that Klb was predominantly expressed in liver and pancreas, with lower levels in skin and weak expression in stomach, skeletal muscle, small intestine, and lung. In mouse embryos, Klb expression became detectable at day 11 and increased in intensity as development progressed. In situ hybridization of mouse embryos revealed strong Klb expression in yolk sac, gut, brown and white adipose tissue, liver, and pancreas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH756Hu01 Recombinant Klotho Beta (KLb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH756Hu01 Polyclonal Antibody to Klotho Beta (KLb) WB; IHC
LAH756Hu71 Biotin-Linked Polyclonal Antibody to Klotho Beta (KLb) WB; IHC; ICC.
MAH756Hu21 Monoclonal Antibody to Klotho Beta (KLb) WB
LAH756Hu81 FITC-Linked Polyclonal Antibody to Klotho Beta (KLb) WB; IHC; ICC; IF.
Assay Kits SEH756Hu ELISA Kit for Klotho Beta (KLb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH756Mu01 Recombinant Klotho Beta (KLb) Positive Control; Immunogen; SDS-PAGE; WB.
RPH756Mu02 Recombinant Klotho Beta (KLb) Positive Control; Immunogen; SDS-PAGE; WB.
RPH756Mu03 Recombinant Klotho Beta (KLb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH756Mu01 Polyclonal Antibody to Klotho Beta (KLb) WB; IHC; ICC; IP.
PAH756Mu02 Polyclonal Antibody to Klotho Beta (KLb) WB; IHC; ICC; IP.
LAH756Mu71 Biotin-Linked Polyclonal Antibody to Klotho Beta (KLb) WB; IHC; ICC.
PAH756Mu03 Polyclonal Antibody to Klotho Beta (KLb) WB; IHC; ICC; IP.
Assay Kits SEH756Mu ELISA Kit for Klotho Beta (KLb) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors."J. Biol. Chem. 283:33304-33309(2008) [PubMed] [Europe PMC] [Abstract]
  3. "Different roles of N- and C- termini in the functional activity of FGF21."J. Cell. Physiol. 219:227-234(2009) [PubMed] [Europe PMC] [Abstract]