Latexin (LXN)

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ECI; TCI; MUM; Endogenous carboxypeptidase inhibitor; Tissue carboxypeptidase inhibitor

Latexin (LXN)
Latexin is a specific inhibitor of zinc-dependent metallocarboxypeptidases. The deduced 222-amino acid protein is an elongated molecule with N- and C-terminal domains that each consist of an alpha helix enveloped by a curved beta sheet. The 2 domains are separated by a connecting segment.Lxn was less potent against other mammalian carboxypeptidases, and it did not inhibit other metallopeptidases or serine proteases.
It also showed low specificity, inhibiting several metallocarboxypeptidases containing a characteristic alpha/beta hydrolase fold. The inhibition constant was within the nanomolar range for these substrates. LXN did not inhibit enzymes of other carboxypeptidase classes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH709Hu01 Recombinant Latexin (LXN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH709Hu01 Polyclonal Antibody to Latexin (LXN) WB; IHC; ICC; IP.
LAH709Hu71 Biotin-Linked Polyclonal Antibody to Latexin (LXN) WB; IHC; ICC.
LAH709Hu81 FITC-Linked Polyclonal Antibody to Latexin (LXN) WB; IHC; ICC; IF.
PAH709Hu02 Polyclonal Antibody to Latexin (LXN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Latexin (LXN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Latexin (LXN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH709Mu01 Recombinant Latexin (LXN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH709Mu01 Polyclonal Antibody to Latexin (LXN) WB; IHC; ICC; IP.
LAH709Mu71 Biotin-Linked Polyclonal Antibody to Latexin (LXN) WB; IHC; ICC.
Assay Kits SEH709Mu ELISA Kit for Latexin (LXN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH709Ra01 Recombinant Latexin (LXN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH709Ra01 Polyclonal Antibody to Latexin (LXN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Latexin (LXN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Latexin (LXN) ELISA Kit Customized Service Offer
  1. "Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor."Mol. Biol. Rep. 27:241-246(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin."Proc. Natl. Acad. Sci. U.S.A. 102:3978-3983(2005) [PubMed] [Europe PMC] [Abstract]