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Thyroid Hormone Receptor Interactor 6 (TRIP6)

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OIP1; ZRP-1; Opa-interacting protein 1; Zyxin-related protein 1

Thyroid Hormone Receptor Interactor 6 (TRIP6)
CCC H002
HGNC 12311
MGI 1343458
PubMed 16880273
UniProt Q15654
Wiki TRIP6
TRIP6 is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.Deconvolution microscopy demonstrated diffuse cytoplasmic colocalization of srfH and Trip6 in murine macrophages. Bacteria lacking SrfH were unable to stimulate TRIP6-dependent phagocyte migration in vitro or in vivo. Mice lacking Cd18 and infected with Salmonella did not show phagocyte migration, in spite of diminished bactericidal function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH002Hu01 Recombinant Thyroid Hormone Receptor Interactor 6 (TRIP6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH002Hu01 Polyclonal Antibody to Thyroid Hormone Receptor Interactor 6 (TRIP6) WB; IHC; ICC; IP.
Assay Kits SEH002Hu ELISA Kit for Thyroid Hormone Receptor Interactor 6 (TRIP6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH002Mu01 Recombinant Thyroid Hormone Receptor Interactor 6 (TRIP6) Positive Control; Immunogen; SDS-PAGE; WB.
RPH002Mu02 Recombinant Thyroid Hormone Receptor Interactor 6 (TRIP6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH002Mu01 Polyclonal Antibody to Thyroid Hormone Receptor Interactor 6 (TRIP6) WB; IHC; ICC; IP.
PAH002Mu02 Polyclonal Antibody to Thyroid Hormone Receptor Interactor 6 (TRIP6) WB; IHC; ICC; IP.
Assay Kits SEH002Mu ELISA Kit for Thyroid Hormone Receptor Interactor 6 (TRIP6) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis."Genomics 49:314-316(1998) [PubMed] [Europe PMC] [Abstract]
  2. "ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E."J. Biol. Chem. 274:20679-20687(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]
  9. "A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters."Genes Dev. 18:2518-2528(2004) [PubMed] [Europe PMC] [Abstract]
  10. "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor."J. Biol. Chem. 279:10459-10468(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins."FEBS Lett. 579:5061-5068(2005) [PubMed] [Europe PMC] [Abstract]
  12. "c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration."Mol. Cell. Biol. 25:5859-5868(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  14. "TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase."Cell. Signal. 18:1702-1712(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Supervillin modulation of focal adhesions involving TRIP6/ZRP-1."J. Cell Biol. 174:447-458(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Salmonella typhimurium disseminates within its host by manipulating the motility of infected cells."Proc. Natl. Acad. Sci. U.S.A. 103:17915-17920(2006) [PubMed] [Europe PMC] [Abstract]
  17. "PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration."J. Biol. Chem. 282:24381-24387(2007) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness."FASEB J. 23:916-928(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Solution structure of the first and second LIM domain of thyroid receptor interacting protein 6 (TRIP6)."Submitted (OCT-2006) to the PDB data bank