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TTK Protein Kinase (TTK)

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MPS1; MPS1L1; CT96; PYT; Cancer/Testis Antigen 96; Phosphotyrosine picked threonine-protein kinase; Dual specificity protein kinase TTK

TTK Protein Kinase (TTK)
CCC G991
HGNC 12401
MGI 1194921
PubMed 1639825
RGD 1305558
UniProt P33981
Wiki TTK
Protein kinases are generally divided into 2 broad classes based on their ability to phosphorylate either tyrosine (tyr) or serine/threonine (ser/thr) residues. However, several protein kinases have dual specificity and are able to phosphorylate all 3 amino acids.TTK encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG991Hu01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG991Hu01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB,IHC,ICC/IF
Assay Kits n/a CLIA Kit for TTK Protein Kinase (TTK) CLIA Kit Customized Service Offer
n/a ELISA Kit for TTK Protein Kinase (TTK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG991Mu01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG991Mu01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TTK Protein Kinase (TTK) CLIA Kit Customized Service Offer
n/a ELISA Kit for TTK Protein Kinase (TTK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG991Ra01 Recombinant TTK Protein Kinase (TTK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG991Ra01 Polyclonal Antibody to TTK Protein Kinase (TTK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for TTK Protein Kinase (TTK) CLIA Kit Customized Service Offer
n/a ELISA Kit for TTK Protein Kinase (TTK) ELISA Kit Customized Service Offer
  1. "Expression of TTK, a novel human protein kinase, is associated with cell proliferation."J. Biol. Chem. 267:16000-16006(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine."Oncogene 8:351-359(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members."Methods Enzymol. 200:38-62(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment."Cell 132:233-246(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator."J. Cell Biol. 184:647-657(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125."J. Biol. Chem. 283:21495-21500(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Structural and mechanistic insights into Mps1 kinase activation."J. Cell. Mol. Med. 13:1679-1694(2009) [PubMed] [Europe PMC] [Abstract]