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G Protein Coupled Receptor 78 (GPR78)

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G Protein Coupled Receptor 78 (GPR78)
CCC G738
HGNC 4528
PubMed 16389273
UniProt Q96P69
Wiki GPR78
The response depended upon the cell line studied. UV-B was a weaker inducer, and UV-C and several other DNA-damaging agents did not induce GPR78 expression. Induction of GPR78 by tunicamycin required activation of multiple ER stress-response elements in the promoter of the GPR78 gene, and induction by a DNA-alkylating agent was independent of the unfolded protein response.
GPR78 encodes a deduced 363-amino acid protein that shares 56% sequence identity with GPR26 in the transmembrane region. Northern blot analysis revealed a 1.1-kb transcript in pituitary, and 1.1- and 4.2-kb transcripts in placenta. No expression was detected in brain, skeletal muscle, lung, heart, liver, pancreas, or kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG738Hu01 Recombinant G Protein Coupled Receptor 78 (GPR78) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG738Hu21 Monoclonal Antibody to G Protein Coupled Receptor 78 (GPR78) WB; IHC; ICC; IP.
PAG738Hu01 Polyclonal Antibody to G Protein Coupled Receptor 78 (GPR78) WB; IHC; ICC; IP.
Assay Kits SEG738Hu ELISA Kit for G Protein Coupled Receptor 78 (GPR78) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Discovery and mapping of ten novel G protein-coupled receptor genes."Gene 275:83-91(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78."Biochim. Biophys. Acta 1770:890-901(2007) [PubMed] [Europe PMC] [Abstract]