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Lysophosphatidylcholine Acyltransferase 2 (LPCAT2)

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AYTL1; Acyltransferase Like 1; 1-acylglycerol-3-phosphate O-acyltransferase 11; Lysophosphatidic acid acyltransferase alpha; 1-alkylglycerophosphocholine O-acetyltransferase

Lysophosphatidylcholine Acyltransferase 2 (LPCAT2)
CCC G530
HGNC 26032
MGI 3606214
PubMed 22233193
UniProt Q7L5N7
LPCAT2 encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine.
The protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The deduced full-length protein contains an N-terminal catalytic domain and 2 cation-binding EF-hand motifs in its C-terminal region.Epitope-tagged Lpcat2 was expressed mainly in the ER and Golgi of transfected Chinese hamster ovary cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG530Hu01 Recombinant Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG530Hu01 Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) WB; IHC; ICC; IP.
MAG530Hu21 Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) WB; IHC; ICC; IP.
Assay Kits SEG530Hu ELISA Kit for Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG530Mu01 Recombinant Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) Positive Control; Immunogen; SDS-PAGE; WB.
RPG530Mu02 Recombinant Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG530Mu01 Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) WB; IHC; ICC; IP.
PAG530Mu02 Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) WB; IHC; ICC; IP.
Assay Kits SEG530Mu ELISA Kit for Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG530Ra01 Recombinant Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) ELISA Kit Customized Service Offer
  1. "A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:lyso-PAF acetyltransferase."J. Biol. Chem. 282:6532-6539(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers."J. Lipid Res. 51:2143-2152(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine."J. Biol. Chem. 286:21330-21339(2011) [PubMed] [Europe PMC] [Abstract]