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Phosphopantothenoylcysteine Decarboxylase (PPCDC)

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COAC; PPC-DC

Phosphopantothenoylcysteine Decarboxylase (PPCDC)
CCC G478
HGNC 28107
MGI 1914062
PubMed 23962284
RGD 1306267
UniProt Q96CD2
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine. PPCDC functioned within the CoA synthetic pathway, and they verified PPCDC function by complementation in E. coli. Incubation of PPCS, PPCDC, and the bifunctional enzyme COASY with the necessary substrates and cofactors reconstituted the 4-step biochemical transformation of phosphopantothenate to CoA. Saccharomyces cerevisiae Hal3 and Vhs3 are moonlighting proteins, forming an atypical heterotrimeric decarboxylase (PPCDC) required for CoA biosynthesis, and regulating cation homeostasis by inhibition of the Ppz1 phosphatase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG478Hu01 Recombinant Phosphopantothenoylcysteine Decarboxylase (PPCDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Phosphopantothenoylcysteine Decarboxylase (PPCDC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphopantothenoylcysteine Decarboxylase (PPCDC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphopantothenoylcysteine Decarboxylase (PPCDC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphopantothenoylcysteine Decarboxylase (PPCDC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG478Mu01 Recombinant Phosphopantothenoylcysteine Decarboxylase (PPCDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Phosphopantothenoylcysteine Decarboxylase (PPCDC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphopantothenoylcysteine Decarboxylase (PPCDC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphopantothenoylcysteine Decarboxylase (PPCDC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphopantothenoylcysteine Decarboxylase (PPCDC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG478Ra01 Recombinant Phosphopantothenoylcysteine Decarboxylase (PPCDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Phosphopantothenoylcysteine Decarboxylase (PPCDC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphopantothenoylcysteine Decarboxylase (PPCDC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphopantothenoylcysteine Decarboxylase (PPCDC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphopantothenoylcysteine Decarboxylase (PPCDC) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics."J. Biol. Chem. 277:21431-21439(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent."Biochemistry 43:15520-15533(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase."Acta Crystallogr. D 59:1762-1766(2003) [PubMed] [Europe PMC] [Abstract]