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Glycine Dehydrogenase (GLDC)

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GCSP; NKH; Decarboxylating; Glycine Decarboxylase; Glycine Cleavage System Protein P; Glycine dehydrogenase (aminomethyl-transferring)

Glycine Dehydrogenase (GLDC)
CCC G475
HGNC 4313
MGI 1341155
PubMed 21107318
RGD 1308660
UniProt P23378
Wiki GLDC
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase).
GLDC is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). The GLDC gene spans at least 135 kb and contains 25 exons. All donor and acceptor sites adhered to the canonical GT-AG rule, except for the donor site of intron 21, where a variant form GC is used instead of GT.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG475Hu01 Recombinant Glycine Dehydrogenase (GLDC) Positive Control; Immunogen; SDS-PAGE; WB.
RPG475Hu02 Recombinant Glycine Dehydrogenase (GLDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG475Hu02 Polyclonal Antibody to Glycine Dehydrogenase (GLDC) WB; IHC; ICC; IP.
PAG475Hu01 Polyclonal Antibody to Glycine Dehydrogenase (GLDC) WB; IHC; ICC; IP.
LAG475Hu71 Biotin-Linked Polyclonal Antibody to Glycine Dehydrogenase (GLDC) WB; IHC; ICC.
Assay Kits SCG475Hu CLIA Kit for Glycine Dehydrogenase (GLDC) Chemiluminescent immunoassay for Antigen Detection.
SEG475Hu ELISA Kit for Glycine Dehydrogenase (GLDC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG475Mu01 Recombinant Glycine Dehydrogenase (GLDC) Positive Control; Immunogen; SDS-PAGE; WB.
RPG475Mu02 Recombinant Glycine Dehydrogenase (GLDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG475Mu01 Polyclonal Antibody to Glycine Dehydrogenase (GLDC) WB; IHC; ICC; IP.
PAG475Mu02 Polyclonal Antibody to Glycine Dehydrogenase (GLDC) WB; IHC; ICC; IP.
Assay Kits SEG475Mu ELISA Kit for Glycine Dehydrogenase (GLDC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG475Ra01 Recombinant Glycine Dehydrogenase (GLDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG475Ra21 Monoclonal Antibody to Glycine Dehydrogenase (GLDC) WB; IHC; ICC; IP.
PAG475Ra01 Polyclonal Antibody to Glycine Dehydrogenase (GLDC) WB; IHC; ICC; IP.
Assay Kits SEG475Ra ELISA Kit for Glycine Dehydrogenase (GLDC) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structural and expression analyses of normal and mutant mRNA encoding glycine decarboxylase: three-base deletion in mRNA causes nonketotic hyperglycinemia."Biochem. Biophys. Res. Commun. 174:1176-1182(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures."J. Biol. Chem. 266:3323-3329(1991) [PubMed] [Europe PMC] [Abstract]
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  9. "Identification of a common mutation in Finnish patients with nonketotic hyperglycinemia."J. Clin. Invest. 90:160-164(1992) [PubMed] [Europe PMC] [Abstract]
  10. "Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel T-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH)."Mol. Genet. Metab. 72:322-325(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Nonketotic hyperglycinemia (glycine encephalopathy): laboratory diagnosis."Mol. Genet. Metab. 74:139-146(2001) [PubMed] [Europe PMC] [Abstract]