Cerebral Dopamine Neurotrophic Factor (CDNF)

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ARMETL1; ARMET-like protein 1; Conserved Dopamine Neurotrophic Factor; Arginine-Rich,Mutated In Early Stage Tumors-Like 1

Cerebral Dopamine Neurotrophic Factor (CDNF)
CDNF shares 59% amino acid identity with human MANF, and 49% and 46% identity with D. melanogaster and C. elegans Manf proteins, respectively. In the midbrain, Cdnf mRNA was expressed from embryonic stages to the adult. High levels of Cdnf mRNA were observed in adult mouse heart, skeletal muscle, and testis. In agreement with the results from mouse, wide expression of CDNF transcripts was detected in human brain and nonneuronal tissues. Interestingly, levels of CDNF transcripts were relatively high in the corpus callosum and optic nerve, which are devoid of neuronal cell bodies and contain mostly axonal projections and oligodendrocytes. At postnatal stage P10 of the mouse brain, Cdnf staining was most intense in the hippocampus and thalamus. Cdnf signal was also detected in striatum and substantia nigra.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG458Hu01 Recombinant Cerebral Dopamine Neurotrophic Factor (CDNF) Positive Control; Immunogen; SDS-PAGE; WB.
EPG458Hu61 Eukaryotic Cerebral Dopamine Neurotrophic Factor (CDNF) Positive Control; Immunogen; SDS-PAGE; WB.
APG458Hu61 Active Cerebral Dopamine Neurotrophic Factor (CDNF) Cell culture; Activity Assays.
Antibodies PAG458Hu01 Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
MAG458Hu21 Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC
PAG458Hu06 Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
MAG458Hu22 Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
MAG458Hu26 Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
Assay Kits SEG458Hu ELISA Kit for Cerebral Dopamine Neurotrophic Factor (CDNF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG458Mu01 Recombinant Cerebral Dopamine Neurotrophic Factor (CDNF) Positive Control; Immunogen; SDS-PAGE; WB.
RPG458Mu02 Recombinant Cerebral Dopamine Neurotrophic Factor (CDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG458Mu01 Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
MAG458Mu22 Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
PAG458Mu02 Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
MAG458Mu21 Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
MAG458Mu23 Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cerebral Dopamine Neurotrophic Factor (CDNF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cerebral Dopamine Neurotrophic Factor (CDNF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG458Ra01 Recombinant Cerebral Dopamine Neurotrophic Factor (CDNF) Positive Control; Immunogen; SDS-PAGE; WB.
RPG458Ra02 Recombinant Cerebral Dopamine Neurotrophic Factor (CDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG458Ra01 Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
PAG458Ra02 Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
LAG458Ra71 Biotin-Linked Polyclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC.
MAG458Ra21 Monoclonal Antibody to Cerebral Dopamine Neurotrophic Factor (CDNF) WB; IHC; ICC; IP.
Assay Kits SEG458Ra ELISA Kit for Cerebral Dopamine Neurotrophic Factor (CDNF) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo."Nature 448:73-77(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death."Exp. Cell Res. 314:2454-2467(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional."Protein Eng. Des. Sel. 22:233-241(2009) [PubMed] [Europe PMC] [Abstract]