Channel Activating Protease 1 (CAP1)

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PRSS8; Prostasin; Protease, Serine 8

Channel Activating Protease 1 (CAP1)
PRSS8 encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The 3-prime end of the cDNA was obtained by the RACE method. A 1.8-kb cDNA sequence was assembled encoding a predicted protein of 343 amino acids which contains a 32-amino acid signal peptide. The protein, designated serine protease-8 (PRSS8), was called prostasin by the authors. The precursor, proprostasin, is cleaved between residues 12 and 13 to produce a 12-amino acid light chain and a 299-amino acid heavy chain which are associated through a disulfide bond. The predicted amino acid sequence is between 34 and 42% identical to human acrosin, plasma kallikrein, and hepsin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG321Hu01 Recombinant Channel Activating Protease 1 (CAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG321Hu01 Polyclonal Antibody to Channel Activating Protease 1 (CAP1) WB; IHC; ICC; IP.
MAG321Hu21 Monoclonal Antibody to Channel Activating Protease 1 (CAP1) WB; IHC; ICC; IP.
Assay Kits SEG321Hu ELISA Kit for Channel Activating Protease 1 (CAP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG321Mu01 Recombinant Channel Activating Protease 1 (CAP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPG321Mu02 Recombinant Channel Activating Protease 1 (CAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG321Mu01 Polyclonal Antibody to Channel Activating Protease 1 (CAP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Channel Activating Protease 1 (CAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Channel Activating Protease 1 (CAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG321Ra01 Recombinant Channel Activating Protease 1 (CAP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPG321Ra02 Recombinant Channel Activating Protease 1 (CAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG321Ra01 Polyclonal Antibody to Channel Activating Protease 1 (CAP1) WB; IHC; ICC; IP.
LAG321Ra81 FITC-Linked Polyclonal Antibody to Channel Activating Protease 1 (CAP1) WB; IHC; ICC; IF.
LAG321Ra71 Biotin-Linked Polyclonal Antibody to Channel Activating Protease 1 (CAP1) WB; IHC; ICC.
PAG321Ra02 Polyclonal Antibody to Channel Activating Protease 1 (CAP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Channel Activating Protease 1 (CAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Channel Activating Protease 1 (CAP1) ELISA Kit Customized Service Offer
  1. "Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA."J. Biol. Chem. 270:13483-13489(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland."J. Biol. Chem. 269:18843-18848(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line."Am. J. Physiol. 287:L928-L935(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Biochemical characterization of prostasin, a channel activating protease."Biochem. Biophys. Res. Commun. 324:953-963(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations."Protein Sci. 18:1081-1094(2009) [PubMed] [Europe PMC] [Abstract]