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Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61)

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CCN1; GIG1; IGFBP10; CCN family member 1; Insulin-like growth factor-binding protein 10

Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61)
CCC G313
HGNC 2654
MGI 88613
PubMed 22547695
RGD 620763
UniProt O00622
Wiki CYR61
CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and augments growth factor-induced DNA synthesis in the same cell type.
The transcription of immediate-early genes is induced rapidly when cells are stimulated by growth factors or transforming oncogenes.The human CYR61 gene encodes a predicted 382-amino acid protein that is 93% identical to the mouse protein, and contains 10% cysteine residues and a 24-amino acid N-terminal signal sequence. Northern blot analysis revealed 2.5-kb and minor 4-kb CYR61 mRNAs that are expressed widely at varying levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG313Hu01 Recombinant Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Positive Control; Immunogen; SDS-PAGE; WB.
APG313Hu01 Active Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Cell culture; Activity Assays.
Antibodies PAG313Hu01 Polyclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) IHC
MAG313Hu21 Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) WB
MAG313Hu26 Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) WB
MAG313Hu22 Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) WB
MAG313Hu23 Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) WB
MAG313Hu24 Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) WB
MAG313Hu25 Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) WB
Assay Kits SEG313Hu ELISA Kit for Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG313Mu01 Recombinant Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Positive Control; Immunogen; SDS-PAGE; WB.
RPG313Mu02 Recombinant Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG313Mu01 Polyclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) WB; IHC
PAG313Mu02 Polyclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) WB; IHC; ICC; IP.
Assay Kits SEG313Mu ELISA Kit for Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) ELISA Kit Customized Service Offer
  1. "The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p."Oncogene 14:1753-1757(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system."Mol. Pathol. 50:310-316(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61."J. Biol. Chem. 275:28929-28936(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Organization and expression of the Cyr61 gene in normal human fibroblasts."J. Biomed. Sci. 9:59-67(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts."J. Biol. Chem. 276:47329-47337(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3."J. Biol. Chem. 273:3090-3096(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)."J. Biol. Chem. 274:24321-24327(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans."J. Biol. Chem. 275:24953-24961(2000) [PubMed] [Europe PMC] [Abstract]
  10. "CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain."J. Biol. Chem. 276:21943-21950(2001) [PubMed] [Europe PMC] [Abstract]