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Podocan (PODN)

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PCAN; SLRR5A

Podocan (PODN)
CCC G186
HGNC 23174
MGI 2674939
PubMed 12796502
UniProt Q7Z5L7
Mouse and human PODN proteins share greater than 91% amino acid identity. Podocan is highly homologous to members of the small leucine-rich repeat protein (SLRP) family, which are proteoglycans that regulate and maintain extracellular matrix collagen fibrils. Podocan contains an N-terminal cysteine-rich cluster pattern and an acidic C-terminal domain distinct from that of other SLRP family members, suggesting that podocan defines a novel SLRP phylogenetic class. Northern blot analysis of normal mouse kidney RNA showed varied expression of 3.2- and 2.3-kb murine PODN transcripts, beginning at embryonic day 14 and continuing through adulthood. RNA in situ hybridization showed expression of PODN in podocytes and vascular endothelial cells within the glomeruli of adult mouse kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG186Hu01 Recombinant Podocan (PODN) Positive Control; Immunogen; SDS-PAGE; WB.
RPG186Hu02 Recombinant Podocan (PODN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG186Hu01 Polyclonal Antibody to Podocan (PODN) WB; IHC; ICC; IP.
PAG186Hu02 Polyclonal Antibody to Podocan (PODN) WB; IHC; ICC; IP.
Assay Kits SEG186Hu ELISA Kit for Podocan (PODN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG186Mu01 Recombinant Podocan (PODN) Positive Control; Immunogen; SDS-PAGE; WB.
RPG186Mu02 Recombinant Podocan (PODN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG186Mu01 Polyclonal Antibody to Podocan (PODN) WB; IHC; ICC; IP.
PAG186Mu02 Polyclonal Antibody to Podocan (PODN) WB; IHC; ICC; IP.
Assay Kits SEG186Mu ELISA Kit for Podocan (PODN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy."J. Biol. Chem. 278:33248-33255(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Functional characterization of podocan, a member of a new class in the small leucine-rich repeat protein family."FEBS Lett. 563:69-74(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Proteomics characterization of extracellular space components in the human aorta."Mol. Cell. Proteomics 9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]