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Histidyl tRNA Synthetase 2, Mitochondrial (HARS2)

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HARSL; HARSR; HO3; HisRS; Histidyl tRNA Synthetase-Like; Histidyl-tRNA synthetase

Histidyl tRNA Synthetase 2, Mitochondrial (HARS2)
CCC G130
HGNC 4817
MGI 1918041
PubMed 7755634
UniProt P49590
Wiki HARS2
HARS2 is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter.
The deduced 506-amino acid HO3 protein has a calculated molecular mass of 56.9 kD. HO3 shares 72% amino acid identity with HARS. Both proteins contain 3 motifs conserved among class II aminoacyl-tRNA synthetases and 2 signature regions of histidyl-tRNA synthetases. However, HARS and HARS2 have divergent N-terminal domains that are encoded by the first 2 exons of each gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG130Hu01 Recombinant Histidyl tRNA Synthetase 2, Mitochondrial (HARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Histidyl tRNA Synthetase 2, Mitochondrial (HARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histidyl tRNA Synthetase 2, Mitochondrial (HARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histidyl tRNA Synthetase 2, Mitochondrial (HARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histidyl tRNA Synthetase 2, Mitochondrial (HARS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG130Mu01 Recombinant Histidyl tRNA Synthetase 2, Mitochondrial (HARS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Histidyl tRNA Synthetase 2, Mitochondrial (HARS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histidyl tRNA Synthetase 2, Mitochondrial (HARS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histidyl tRNA Synthetase 2, Mitochondrial (HARS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histidyl tRNA Synthetase 2, Mitochondrial (HARS2) ELISA Kit Customized Service Offer
  1. "A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS."Biochem. Biophys. Res. Commun. 210:556-566(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome."Proc. Natl. Acad. Sci. U.S.A. 108:6543-6548(2011) [PubMed] [Europe PMC] [Abstract]