Phosphatase And Tensin Homolog (PTEN)

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BZS; MHAM; MMAC1; PTEN1; TEP1; Mutated In Multiple Advanced Cancers 1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Phosphatase And Tensin Homolog (PTEN)
PTEN acts as a tumor suppressor gene through the action of its phosphatase protein product. This phosphatase is involved in the regulation of the cell cycle, preventing cells from growing and dividing too rapidly.This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating Akt/PKB signaling pathway.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF822Hu01 Recombinant Phosphatase And Tensin Homolog (PTEN) Positive Control; Immunogen; SDS-PAGE; WB.
APF822Hu01 Active Phosphatase And Tensin Homolog (PTEN) Cell culture; Activity Assays.
Antibodies PAF822Hu01 Polyclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB; IHC; ICC; IP; FCM
LAF822Hu71 Biotin-Linked Polyclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB; IHC; ICC.
MAF822Hu21 Monoclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB; IHC; ICC; IP.
MAF822Hu22 Monoclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB; IHC; ICC; IP.
MAF822Hu23 Monoclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB; IHC
Assay Kits SEF822Hu ELISA Kit for Phosphatase And Tensin Homolog (PTEN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF822Mu01 Recombinant Phosphatase And Tensin Homolog (PTEN) Positive Control; Immunogen; SDS-PAGE; WB.
RPF822Mu02 Recombinant Phosphatase And Tensin Homolog (PTEN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF822Mu01 Polyclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB; IHC; ICC; IP.
PAF822Mu02 Polyclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB; IHC; ICC; IP.
Assay Kits SEF822Mu ELISA Kit for Phosphatase And Tensin Homolog (PTEN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF822Ra01 Recombinant Phosphatase And Tensin Homolog (PTEN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAF822Ra21 Monoclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB; IHC; ICC; IP.
PAF822Ra01 Polyclonal Antibody to Phosphatase And Tensin Homolog (PTEN) WB; IHC; ICC; IP.
Assay Kits SEF822Ra ELISA Kit for Phosphatase And Tensin Homolog (PTEN) Enzyme-linked immunosorbent assay for Antigen Detection.
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  28. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  29. "A secreted PTEN phosphatase that enters cells to alter signaling and survival." Science 341:399-402(2013) [PubMed] [Europe PMC] [Abstract]
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  38. "Germline mutations in PTEN are present in Bannayan-Zonana syndrome."Nat. Genet. 16:333-334(1997) [PubMed] [Europe PMC] [Abstract]
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  46. "Variant manifestation of Cowden disease in Japan: hamartomatous polyposis of the digestive tract with mutation of the PTEN gene."Am. J. Hum. Genet. 64:308-310(1999) [PubMed] [Europe PMC] [Abstract]
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  48. "Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations."Eur. J. Hum. Genet. 7:267-273(1999) [PubMed] [Europe PMC] [Abstract]
  49. "PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome." Hum. Mol. Genet. 8:1461-1472(1999) [PubMed] [Europe PMC] [Abstract]
  50. "Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay."Cancer Res. 60:3147-3151(2000) [PubMed] [Europe PMC] [Abstract]
  51. "Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers."J. Med. Genet. 37:336-341(2000) [PubMed] [Europe PMC] [Abstract]
  52. "Identification of PTEN mutations in metastatic melanoma specimens."J. Med. Genet. 37:653-657(2000) [PubMed] [Europe PMC] [Abstract]
  53. "PTEN coordinates G1 arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model."Hum. Mol. Genet. 10:599-604(2001) [PubMed] [Europe PMC] [Abstract]
  54. "A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association."J. Med. Genet. 38:820-823(2001) [PubMed] [Europe PMC] [Abstract]
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  57. "Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10."Cancer Genet. Cytogenet. 132:20-24(2002) [PubMed] [Europe PMC] [Abstract]
  58. "Germline mutation of the tumour suppressor PTEN in Proteus syndrome."J. Med. Genet. 39:937-940(2002) [PubMed] [Europe PMC] [Abstract]
  59. "Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations."J. Med. Genet. 42:318-321(2005) [PubMed] [Europe PMC] [Abstract]
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  61. "A germline PTEN mutation with manifestations of prenatal onset and verrucous epidermal nevus."Am. J. Med. Genet. A 140:1472-1475(2006) [PubMed] [Europe PMC] [Abstract]