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Neuroligin 4, X-Linked (NLGN4X)

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ASPGX2; AUTSX2; HLNX; HNLX; NLGN; NLGN4; Neuroligin 4

Neuroligin 4, X-Linked (NLGN4X)
CCC F669
HGNC 14287
PubMed 23710042
UniProt Q8N0W4
Wiki NLGN4X
NLGN4X encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Murine Nlgn4 was expressed in mouse thymus and brain, with highest expression in hippocampus, cortex, and septum, and lowest expression in brainstem and cerebellum. Nlgn4 expression increased from low levels during embryonic and early postnatal phases to reach a plateau at 3 weeks after birth, consistent with synaptic expression. Subcellular fractionation of brain homogenates showed enrichment of Nlgn4 in synaptic membrane fractions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF669Hu01 Recombinant Neuroligin 4, X-Linked (NLGN4X) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Neuroligin 4, X-Linked (NLGN4X) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neuroligin 4, X-Linked (NLGN4X) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neuroligin 4, X-Linked (NLGN4X) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuroligin 4, X-Linked (NLGN4X) ELISA Kit Customized Service Offer
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  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Binding of neuroligins to PSD-95."Science 277:1511-1515(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression."Biochem. J. 356:581-588(2001) [PubMed] [Europe PMC] [Abstract]
  8. "X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family."Am. J. Hum. Genet. 74:552-557(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion."Neuron 56:979-991(2007) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]