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Uridine Cytidine Kinase 1 (UCK1)

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URK1; Cytidine monophosphokinase 1; Uridine monophosphokinase 1

Uridine Cytidine Kinase 1 (UCK1)
CCC F555
HGNC 14859
MGI 98904
PubMed 24192812
UniProt Q9HA47
Uridine/cytidine kinase-1 (EC 2.7.1.48) is a pyrimidine ribonucleoside kinase that catalyzes the phosphorylation of uridine and cytidine to form uridine monophosphate (UMP) and cytidine monophosphate (CMP) .
By searching for sequences similar to mouse uridine/cytidine kinase, followed by PCR of a fetal brain cDNA library, Van Rompay et al. (2001) cloned UCK1. The deduced 277-amino acid protein has a calculated molecular mass of 31 kD. UCK1 shares 92% amino acid identity with mouse Uck1 and 72% similarity with human UCK2 . Northern blot analysis detected a 2.7-kb transcript in all tissues examined, with highest expression in liver, kidney, skeletal muscle, and heart. A 1.8-kb transcript was detected in skeletal muscle, heart, liver, and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF555Hu01 Recombinant Uridine Cytidine Kinase 1 (UCK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Uridine Cytidine Kinase 1 (UCK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Uridine Cytidine Kinase 1 (UCK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Uridine Cytidine Kinase 1 (UCK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Uridine Cytidine Kinase 1 (UCK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF555Mu01 Recombinant Uridine Cytidine Kinase 1 (UCK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Uridine Cytidine Kinase 1 (UCK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Uridine Cytidine Kinase 1 (UCK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Uridine Cytidine Kinase 1 (UCK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Uridine Cytidine Kinase 1 (UCK1) ELISA Kit Customized Service Offer
  1. "Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases."Mol. Pharmacol. 59:1181-1186(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of human uridine-cytidine kinase 1."Submitted (JAN-2007) to the PDB data bank