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Lysyl Oxidase Like Protein 2 (LOXL2)

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LOR2; WS9-14; Lysyl oxidase homolog 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14

Lysyl Oxidase Like Protein 2 (LOXL2)
CCC F552
HGNC 6666
MGI 2137913
PubMed 21233336
RGD 1308435
UniProt Q9Y4K0
Wiki LOXL2
Lysyl oxidase homolog 2 is encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and prostate.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF552Hu01 Recombinant Lysyl Oxidase Like Protein 2 (LOXL2) Positive Control; Immunogen; SDS-PAGE; WB.
RPF552Hu02 Recombinant Lysyl Oxidase Like Protein 2 (LOXL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF552Hu01 Polyclonal Antibody to Lysyl Oxidase Like Protein 2 (LOXL2) WB; IHC; ICC; IP.
PAF552Hu02 Polyclonal Antibody to Lysyl Oxidase Like Protein 2 (LOXL2) WB; IHC; ICC; IP.
Assay Kits SEF552Hu ELISA Kit for Lysyl Oxidase Like Protein 2 (LOXL2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF552Mu01 Recombinant Lysyl Oxidase Like Protein 2 (LOXL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF552Mu01 Polyclonal Antibody to Lysyl Oxidase Like Protein 2 (LOXL2) WB; IHC; ICC; IP.
LAF552Mu71 Biotin-Linked Polyclonal Antibody to Lysyl Oxidase Like Protein 2 (LOXL2) WB; IHC; ICC.
Assay Kits SEF552Mu ELISA Kit for Lysyl Oxidase Like Protein 2 (LOXL2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF552Ra01 Recombinant Lysyl Oxidase Like Protein 2 (LOXL2) Positive Control; Immunogen; SDS-PAGE; WB.
RPF552Ra02 Recombinant Lysyl Oxidase Like Protein 2 (LOXL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF552Ra01 Polyclonal Antibody to Lysyl Oxidase Like Protein 2 (LOXL2) WB; IHC; ICC; IP.
PAF552Ra02 Polyclonal Antibody to Lysyl Oxidase Like Protein 2 (LOXL2) WB; IHC; ICC; IP.
LAF552Ra71 Biotin-Linked Polyclonal Antibody to Lysyl Oxidase Like Protein 2 (LOXL2) WB; IHC; ICC.
LAF552Ra81 FITC-Linked Polyclonal Antibody to Lysyl Oxidase Like Protein 2 (LOXL2) WB; IHC; ICC; IF.
Assay Kits SEF552Ra ELISA Kit for Lysyl Oxidase Like Protein 2 (LOXL2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence."J. Biol. Chem. 272:8157-8160(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues."J. Biol. Chem. 274:12939-12944(1999) [PubMed] [Europe PMC] [Abstract]
  6. "A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression."EMBO J. 24:3446-3458(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1."J. Biol. Chem. 285:6658-6669(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor."J. Biol. Chem. 285:20964-20974(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment." Nat. Med. 16:1009-1017(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane."Blood 118:3979-3989(2011) [PubMed] [Europe PMC] [Abstract]
  11. "LOXL2-mediated matrix remodeling in metastasis and mammary gland involution."Cancer Res. 71:1561-1572(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas."EMBO Mol. Med. 3:528-544(2011) [PubMed] [Europe PMC] [Abstract]
  13. "The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin."Mol. Biol. Rep. 38:145-149(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation."J. Biol. Chem. 287:3541-3549(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Lysyl oxidase-like 2 deaminates lysine 4 in histone H3."Mol. Cell 46:369-376(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Post-translational Modifications of Recombinant Human Lysyl Oxidase-like 2 (rhLOXL2) Secreted from Drosophila S2 Cells."J. Biol. Chem. 288:5357-5363(2013) [PubMed] [Europe PMC] [Abstract]