![Growth Factor Receptor Bound Protein 14 (Grb14)](/upload/item/img/Growth-Factor-Receptor-Bound-Protein-14-(Grb14)-95469.jpg)
Growth factor receptor-bound protein 14 is a protein belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors.
This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPF469Hu01 | Recombinant Growth Factor Receptor Bound Protein 14 (Grb14) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Growth Factor Receptor Bound Protein 14 (Grb14) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Growth Factor Receptor Bound Protein 14 (Grb14) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Growth Factor Receptor Bound Protein 14 (Grb14) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Growth Factor Receptor Bound Protein 14 (Grb14) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPF469Mu01 | Recombinant Growth Factor Receptor Bound Protein 14 (Grb14) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Growth Factor Receptor Bound Protein 14 (Grb14) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Growth Factor Receptor Bound Protein 14 (Grb14) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Growth Factor Receptor Bound Protein 14 (Grb14) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Growth Factor Receptor Bound Protein 14 (Grb14) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPF469Ra01 | Recombinant Growth Factor Receptor Bound Protein 14 (Grb14) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Growth Factor Receptor Bound Protein 14 (Grb14) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Growth Factor Receptor Bound Protein 14 (Grb14) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Growth Factor Receptor Bound Protein 14 (Grb14) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Growth Factor Receptor Bound Protein 14 (Grb14) | ELISA Kit Customized Service Offer |
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- "Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14."J. Biol. Chem. 277:4845-4852(2002) [PubMed] [Europe PMC] [Abstract]
- "The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1."J. Biol. Chem. 279:37518-37527(2004) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14."Nat. Struct. Mol. Biol. 16:833-839(2009) [PubMed] [Europe PMC] [Abstract]
- ErratumNat. Struct. Mol. Biol. 16:1331-1331(2009)
- "Tyrosine phosphorylation of Grb14 by Tie2."Cell Commun. Signal. 8:30-30(2010) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14."Mol. Cell 20:325-333(2005) [PubMed] [Europe PMC] [Abstract]
- "Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]