≡

Fibulin 4 (FBLN4)

[Edit]

EFEMP2; MBP1; UPH1; EGF-Containing Fibulin-Like Extracellular Matrix Protein 2

Fibulin 4 (FBLN4)
CCC F421
HGNC 3219
MGI 1891209
PubMed 22943132
UniProt O95967
Wiki EFEMP2
A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. FBLN4 contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome.EFEMP1 is likewise expressed in a wide range of adult and fetal tissues. In contrast to EFEMP1, however, EFEMP2 was not significantly overexpressed in senescent or quiescent fibroblasts, suggesting a diversity of function within this EGF-like domain subfamily.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF421Hu01 Recombinant Fibulin 4 (FBLN4) Positive Control; Immunogen; SDS-PAGE; WB.
RPF421Hu02 Recombinant Fibulin 4 (FBLN4) Positive Control; Immunogen; SDS-PAGE; WB.
RPF421Hu03 Recombinant Fibulin 4 (FBLN4) Positive Control; Immunogen; SDS-PAGE; WB.
RPF421Hu04 Recombinant Fibulin 4 (FBLN4) Positive Control; Immunogen; SDS-PAGE; WB.
RPF421Hu05 Recombinant Fibulin 4 (FBLN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF421Hu01 Polyclonal Antibody to Fibulin 4 (FBLN4) WB; IHC; ICC; IP.
PAF421Hu02 Polyclonal Antibody to Fibulin 4 (FBLN4) WB; IHC; ICC; IP.
PAF421Hu03 Polyclonal Antibody to Fibulin 4 (FBLN4) WB; IHC; ICC; IP.
PAF421Hu04 Polyclonal Antibody to Fibulin 4 (FBLN4) WB; IHC; ICC; IP.
Assay Kits SEF421Hu ELISA Kit for Fibulin 4 (FBLN4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF421Mu01 Recombinant Fibulin 4 (FBLN4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF421Mu01 Polyclonal Antibody to Fibulin 4 (FBLN4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fibulin 4 (FBLN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibulin 4 (FBLN4) ELISA Kit Customized Service Offer
  1. "Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4."Matrix Biol. 18:469-480(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13."Hum. Genet. 106:66-72(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Solution NMR structure of the EGF-like 1 domain of human fibulin-4."Submitted (JUL-2009) to the PDB data bank
  10. "Fibulin-4: a novel gene for an autosomal recessive cutis laxa syndrome."Am. J. Hum. Genet. 78:1075-1080(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Compound heterozygous mutations in fibulin-4 causing neonatal lethal pulmonary artery occlusion, aortic aneurysm, arachnodactyly, and mild cutis laxa."Am. J. Med. Genet. A 143:2635-2641(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Lethal cutis laxa with contractural arachnodactyly, overgrowth and soft tissue bleeding due to a novel homozygous fibulin-4 gene mutation."Clin. Genet. 76:276-281(2009) [PubMed] [Europe PMC] [Abstract]